25 Longevity Clinics in the USA Advancing Healthspan in 2027

Americans now live longer than at any point in recorded history, but not necessarily healthier. The CDC reported that life expectancy at birth reached 79.0 years in 2024, a record high. A 2024 analysis from Mayo Clinic researchers in JAMA Network Open found the US has the widest gap between lifespan and healthspan of any country studied, at roughly 12 years. Those extra years are often spent managing chronic disease.

That gap explains the rise of longevity clinics in the USA. These providers combine laboratory testing, imaging, risk modeling and lifestyle coaching to find disease risk earlier and to track change over time. Some are hospital programs with decades of history. Others are venture-backed memberships that sell blood panels, full body MRI and prescription therapies directly to consumers.

Three terms matter before comparing providers. Lifespan is the number of years lived. Healthspan is the number of years lived without major disease or disability. Biological age is an estimate of physiological wear, usually calculated from blood markers or DNA methylation, and it can differ from chronological age. The 25 providers below were selected for documented US operations, identifiable clinical or testing services and public information. The list is an editorial selection, not a ranking, and no official census of US longevity clinics exists.

What Makes a Longevity Clinic Different From Traditional Preventive Healthcare?

A longevity clinic is a medical practice or testing service that focuses on extending healthspan through early risk detection, personalized prevention and long-term monitoring. Traditional preventive care follows population guidelines, such as those from the US Preventive Services Task Force. A longevity clinic usually goes further, adding broader biomarker panels, advanced imaging, genetics and sometimes hormone or metabolic therapy.

The distinction is one of intensity and philosophy, not of kind. Primary care already addresses blood pressure, cholesterol, cancer screening and vaccination. Longevity medicine adds more data points and more frequent measurement, and it often targets risk decades before a diagnosis would normally occur.

That approach has real appeal. Roughly 6 in 10 US adults live with at least one chronic disease, and 4 in 10 have two or more, according to the CDC. Heart disease and cancer each caused more than 600,000 deaths in 2024. Catching risk early could matter.

It also carries risk. Screening healthy people can produce false positives, incidental findings and follow-up procedures that cause harm without improving outcomes. Longevity medicine therefore needs the same discipline as any preventive program: tests should have a clear action attached, and the evidence should justify the action.

Language matters too. Established prevention, such as blood pressure control, smoking cessation and exercise, has strong outcome evidence. Marketing terms such as age reversal describe investigational ideas for which human lifespan data do not exist. A reputable clinic separates the two.

Core Services Offered by Longevity Clinics

Most clinics begin with a baseline assessment. This typically includes a comprehensive blood panel, lipid and apolipoprotein B testing, glucose and insulin markers, inflammation markers such as high-sensitivity CRP, and hormone levels. Body composition scans, often DEXA, estimate lean mass, fat mass and bone density. Cardiorespiratory fitness testing, such as VO2 max, is common at physician-led programs.

Imaging and genomics come next at some providers. Full body MRI, coronary artery calcium scoring, carotid ultrasound and genetic sequencing are the most common. Microbiome analysis and epigenetic clocks appear less consistently and have weaker clinical support.

Treatment and coaching complete the model. Nutrition, exercise, sleep and stress plans are standard. Medically supervised therapies, including statins, GLP-1 medications, menopause or testosterone therapy, and peptides, appear at clinics with prescribing clinicians.

Support varies widely. Guideline-backed services include blood pressure, lipid and glucose testing, age-appropriate cancer screening and cardiovascular risk scoring. Services with uncertain benefit for healthy people include whole-body MRI, microbiome testing, epigenetic age tests and most supplement protocols. The American College of Radiology has stated that evidence does not support whole-body MRI screening of people without symptoms.

How Longevity Medicine Measures Healthspan

Healthspan has no single accepted measure. Researchers use a mix of functional, clinical and biological indicators. Functional capacity, such as grip strength, gait speed and VO2 max, predicts mortality in large cohort studies. Cardiometabolic risk markers track the likelihood of heart disease and diabetes. Frailty indexes and disease incidence capture decline over time.

Biological age tests sit in a gray zone. Epigenetic clocks, including the Horvath clock, PhenoAge and DunedinPACE, correlate with mortality risk in research populations. For an individual, however, results can shift between labs and between repeat samples. No trial has shown that lowering a clock score extends life.

The core principle is the difference between surrogate markers and validated outcomes. A lower LDL cholesterol level is a surrogate marker backed by outcome trials. A younger epigenetic age is a surrogate that lacks that proof.

25 Longevity Clinics in the USA Advancing Preventive and Personalized Care

The profiles below group providers by their main delivery model: academic and hospital programs, physician-led longevity practices, testing and membership platforms, imaging providers, and wellness centers. Hospital programs and licensed medical practices differ from consumer testing platforms and recovery studios, and the profiles reflect that. Prices and services change often, so every figure should be confirmed with the provider.

Academic Medical Center Executive Health Programs

1. Mayo Clinic Executive Health (Rochester, MN; Phoenix, AZ; Jacksonville, FL).

The program pairs a single physician coordinator with Mayo specialists in cardiology, imaging, laboratory medicine and more. Assessments typically run one to several days. Mayo reports the program as self-pay, with pricing quoted individually. The model offers deep specialist access and integrated referral, though it focuses on comprehensive evaluation rather than continuous membership coaching.

2. Cleveland Clinic Executive Health (Cleveland, OH).

This hospital-based program delivers a coordinated one-day evaluation with physician review, laboratory testing, imaging and a written summary. Cleveland Clinic’s cardiac expertise shapes the cardiovascular component. Pricing is not publicly listed, and the assessment generally operates outside standard insurance.

3. Mount Sinai Executive Health (New York, NY).

Operating within the Mount Sinai Health System, the program combines preventive screening with access to the system’s specialists. As with other academic programs, a hospital referral network supports any abnormal finding. Fees are quoted on inquiry.

4. Johns Hopkins Executive Health Program (Baltimore, MD).

This program, replacing candidates that could not be corroborated, offers comprehensive physician-led evaluations at an academic medical center. Hopkins specialists in cardiology, oncology and imaging are available for follow-up. Pricing is provided directly.

Physician-Led Longevity and Preventive Practices

5. Fountain Life (Naples, FL, with centers in Florida and Texas).

Founded in 2018 by Peter Diamandis, Tony Robbins and colleagues, Fountain Life sells tiered memberships built around advanced diagnostics. Its assessments include whole-body MRI, genomic testing, coronary imaging and blood panels, followed by physician review. Reviewers report annual costs from about $3,000 to more than $21,000 depending on tier. It is a high-cost, high-intensity model, and independent outcome data are not published.

6. Human Longevity Inc. (San Diego, CA).

Co-founded in 2013 by J. Craig Venter, Peter Diamandis and Robert Hariri, HLI built its program around genome sequencing, MRI and laboratory testing. Its San Diego Health Nucleus assessment, a candidate listed separately, belongs to the same company and is covered here. The company has published research on imaging findings in asymptomatic adults. Pricing is individualized.

7. Biograph (Austin, TX).

Associated with physician Peter Attia, Biograph delivers multi-day assessments that combine imaging, laboratory testing, fitness metrics and clinician planning. The emphasis falls on reducing risk of the major chronic diseases described in Attia’s writing. Publicly reported prices run well into the thousands of dollars, so confirmation with the clinic is advisable.

8. Parsley Health (New York, NY, with telehealth in multiple states).

Founded in 2016, Parsley offers membership-based integrative primary care. Clinicians are licensed physicians and nurse practitioners who order labs and manage chronic conditions with a functional medicine lens. Membership fees are published on its website, and insurance generally does not cover the membership, though some labs may be billed to insurance.

9. Cenegenics (Las Vegas, NV, with clinics nationwide).

Founded in 1997, Cenegenics is among the oldest US age management practices. Its physicians focus on hormone optimization, nutrition and exercise. Hormone therapy for healthy aging remains contested, so patients should discuss risks with an independent physician. Pricing is not published.

10. Next Health (Los Angeles, CA, with multiple US locations).

Next Health combines clinical assessments with a menu of recovery and optimization services, such as red light therapy and IV treatments. Medical staff oversee diagnostics and prescriptions, but some offerings are wellness-oriented without strong outcome evidence.

11. Wild Health (Lexington, KY, with national reach).

Wild Health pairs genomic and blood testing with physician-guided plans. It positions itself around precision medicine for chronic disease prevention. Pricing is posted for membership levels, and results depend heavily on clinician follow-up.

12. Ways2Well (Tennessee, with telehealth in multiple states).

Ways2Well offers physician-supervised hormone and metabolic care. It markets weight management, hormone therapy and peptides. Consumers should confirm prescriber credentials, since services in this category vary in clinical rigor.

13. The Lanby (New York, NY).

The Lanby operates membership-based primary care centers designed around preventive and longevity-oriented care, with in-person physician visits and structured diagnostics. It functions more like a primary care practice than a testing platform. Membership pricing is published by the company.

14. Life Time MIORA (Texas and other states).

MIORA is the longevity clinic arm of Life Time, the large health club operator. It integrates diagnostics and clinician-led plans with the club environment. Its connection to a fitness chain is convenient for exercise adherence, though patients should confirm which services are medically supervised.

15. Defy Medical (Tampa, FL).

Defy Medical focuses on hormone, metabolic and aging-related care with physician oversight. Like other clinics in this niche, its therapies range from established, such as menopause hormone therapy, to investigational. Pricing is quoted after consultation.

16. Marek Health (Texas, with telehealth nationwide).

Marek Health combines extended laboratory panels with physician-prescribed therapy such as testosterone and GLP-1 medications. It is a hybrid of testing platform and telehealth practice, so continuity of care depends on the prescribing clinician.

17. Hone Health (Delaware-incorporated, telehealth in most states).

Hone provides at-home testing and clinician-supervised hormone and metabolic treatment. It is a virtual-first model without imaging, and it works best for people seeking specific hormone evaluation.

18. AgelessRx (telehealth, multiple states).

AgelessRx offers physician consultations for prescriptions marketed for longevity, such as metformin and rapamycin used off-label. The evidence for these drugs as lifespan extenders in humans is still developing. Off-label use carries risk, and prices vary by medication.

Testing and Membership Platforms

19. Function Health (online platform, US lab network).

Founded in 2020, Function sells an annual membership that includes two rounds of blood testing, with more than 100 biomarkers on the main panel. Public pricing was lowered to $365 per year in 2026, according to multiple sources. Function states that it provides test interpretation rather than ongoing treatment. Optional imaging add-ons are available, and in 2025 the company acquired the full-body MRI company Ezra.

20. Superpower (online platform, US lab network).

Founded in 2023, Superpower offers an annual biomarker panel with a biological age score and clinician messaging. Public pricing appears in different amounts across sources, from $199 to $349 a year, and New York and New Jersey members pay more. The variation shows why prices must be confirmed on the day of purchase.

21. InsideTracker (Boston, MA).

Founded in 2009 and spun out of research at Tufts and MIT, InsideTracker analyzes blood, DNA and fitness data and delivers nutrition and lifestyle recommendations. It is a software and testing service, not a medical practice, and recommendations are educational. Test bundles typically cost several hundred dollars.

22. Lifeforce (online platform).

Lifeforce offers biomarker testing plus clinician-supervised hormone and wellness programs by subscription. As a telehealth company, care is delivered remotely. Prospective members should verify prescriber licensing in their state.

Imaging and Recovery Providers

23. Prenuvo (Redwood City, CA, with centers in multiple US cities).

Prenuvo operates whole-body MRI screening centers. The scans can detect tumors and structural abnormalities, but the benefits and harms of screening healthy people remain unproven. Scans are usually self-pay, around $2,500 or more.

24. Upgrade Labs (Santa Monica, CA, franchised).

Founded by biohacker Dave Asprey in 2018, Upgrade Labs is a technology-driven wellness studio featuring red light, cold exposure and vibration platforms. It is not a medical clinic and should not be compared to a physician practice.

25. Restore Hyper Wellness (Scottsdale, AZ, franchised).

Restore operates franchised recovery studios offering cryotherapy, infrared sauna and IV therapy. Like Upgrade Labs, it is a wellness service. Many of its claims lack strong clinical trial support.

Academic Medical Center Programs Versus Private Longevity Clinics

Hospital executive programs offer multidisciplinary depth. Specialists in cardiology, oncology and radiology sit within the same system, so abnormal findings move quickly into diagnostic workup. Research involvement and clinical governance are also stronger. The tradeoffs are cost, limited geographic reach and a lower emphasis on continuous coaching between annual visits.

Private longevity practices usually deliver more frequent contact, broader prescription options and a membership relationship. They can also be more consumer-friendly. However, continuity can depend on a small number of clinicians, referral networks vary, and treatment incentives may favor products sold in-house.

Diagnostic First, Membership Based and Intervention Focused Models

Providers fall into three broad models. Diagnostic-first providers, such as Fountain Life, Prenuvo and Function Health, lead with testing. Membership-based primary care providers, such as Parsley Health and The Lanby, lead with an ongoing physician relationship. Intervention-focused providers, such as Cenegenics, Hone Health and AgelessRx, lead with prescriptions.

These categories are not equivalent. A laboratory testing platform does not provide treatment. A telehealth prescriber is not a replacement for a primary care physician who knows a patient’s full history. A recovery studio is not a medical practice. Readers should match the model to the goal.

Comparing Longevity Clinic Services, Costs and Clinical Supervision

The most important comparison is between diagnostic intensity and physician supervision over time. A clinic that runs 100 biomarkers and a whole-body MRI but offers no structured follow-up may generate anxiety without action. A clinic with fewer tests but a clear plan and a named physician may deliver more value.

Costs span a wide range. Testing platforms charge a few hundred dollars annually. Physician memberships often run in the low thousands. Premium diagnostic programs can cost $15,000 or more. Hospital executive programs typically are self-pay and quoted individually. Insurance rarely covers executive health or longevity memberships, though routine labs ordered by a physician may be billed to a plan.

Risks deserve attention. Unnecessary screening can trigger incidental findings that lead to biopsies and anxiety. Overdiagnosis, which means detecting disease that would never have caused harm, is a recognized issue in cancer imaging. Commercial incentives matter too, since clinics that sell hormones, peptides and supplements profit from treatment.

What Patients Should Examine Before Enrolling

Credentials come first. Patients should confirm that clinicians hold active state licenses, board certification and relevant training, which state medical boards publish. Evidence standards matter next. Clinics should be able to explain why each test is ordered and what decision it informs.

Privacy deserves attention, particularly with genetic data. Patients should ask how data are stored, who can access them and whether they can be sold or shared with third parties. Billing transparency is another must. A clear price list should separate membership fees, tests, imaging and treatments.

Useful questions include these:

• Which tests are guideline-supported and which are exploratory?
• Who reads scans, and what happens to incidental findings?
• What are the emergency referral pathways?
• How does the clinic coordinate with a primary care physician?
• What outcomes does the clinic track and publish?

The Science Behind Healthspan Extension

The strongest evidence belongs to unglamorous interventions. Regular physical activity reduces cardiovascular disease, cancer and all-cause mortality. WHO recommends 150 to 300 minutes of moderate activity weekly plus muscle strengthening on two or more days. Smoking cessation delivers large gains at any age. Blood pressure control matters too, since the SPRINT trial found that targeting a systolic pressure below 120 mm Hg lowered cardiovascular events and mortality compared with a target below 140.

Nutrition quality, sleep and weight management also have broad support. Newer drugs add to the toolbox. In the SELECT trial, semaglutide reduced major cardiovascular events by about 20% in adults with obesity and established heart disease. Statins and lipid-lowering therapies have decades of outcome data.

Biomarkers and genetics sit in the middle. Blood lipids, glucose and blood pressure are validated risk factors. Polygenic risk scores can add some information but remain imperfect and less accurate in non-European populations. Epigenetic clocks remain research tools.

Investigational approaches carry the least certainty. Senolytics, which aim to clear aging cells, are in early human trials. Rapamycin and metformin are under study, and the TAME trial concept aims to test metformin for aging outcomes. Testosterone therapy has been tested for cardiovascular safety in the TRAVERSE trial, which found no excess of major cardiovascular events in hypogonadal men, but it does not show lifespan benefit. NAD+ boosters and many peptides lack outcome trials.

Improving a risk factor is not the same as proving longer life. A drug can lower a lab value yet fail to change outcomes. Only long trials in humans can show whether a longevity intervention extends healthy years.

Who May Benefit From Longevity Clinic Services?

Healthy adults with a family history of early heart disease may benefit from detailed lipid and calcium scoring. People with elevated blood pressure, prediabetes or obesity may gain from structured risk reduction programs. Executives with limited time may value consolidated, one-day evaluations. Older adults may benefit most from functional assessments, such as gait speed and frailty screening.

Consider three illustrative scenarios. A 48-year-old with a parent who had an early heart attack may use advanced lipid testing and calcium scoring to decide on statin therapy. A 55-year-old with no symptoms may pursue whole-body imaging and receive an incidental finding that requires further testing. A 70-year-old may use a geriatric-style assessment to build a strength and fall-prevention plan. These examples show how outcomes depend on the person and the plan.

Primary care or specialist care may be more appropriate for anyone with active symptoms, known disease or complex medication needs. A primary care physician provides continuity and is covered by insurance.

Affordability is a serious limitation. A premium membership can cost more than many households spend on all medical care in a year. Health literacy also matters, because test results are only useful when patients understand them. Wealthier Americans benefit from earlier screening while lower-income groups face more barriers to basic preventive care. Longevity services risk widening that gap.

Risks, Limitations and Ethical Questions in Longevity Medicine

Overtesting is the most common concern. Every additional test increases the chance of a false positive, and false positives create costs, anxiety and sometimes harm from invasive follow-up. Biological age estimates can vary by test, making them poor tools for tracking individual progress.

Unproven treatments are another risk. Hormones, peptides and off-label drugs can cause side effects, and long-term data are lacking. Conflicts of interest arise when clinics profit from products they recommend.

Data privacy requires care. Genetic and health information is sensitive and, outside of HIPAA-covered entities, may be less protected. Direct-to-consumer laboratory tests also have limitations, since results may not be reviewed by a clinician who knows the patient.

Commercial claims should be weighed against peer-reviewed evidence and regulatory status. The FDA regulates drugs and medical devices, but many laboratory-developed tests and supplements face lighter oversight. Consumers should be skeptical of any provider that claims it can reverse aging.

The Future of Longevity Clinics in America

Artificial intelligence may improve risk prediction by combining lab results, imaging, wearable data and electronic records. Longitudinal data could help clinicians spot subtle trends sooner. Remote monitoring, through wearable devices and home testing, may make continuous measurement more affordable.

Integration with primary care and health systems is another possibility. If preventive medicine moves into insurance-covered care, access could widen. Several health systems are already exploring preventive programs.

Research gaps remain large. No long-term trial has shown that a comprehensive longevity clinic assessment extends healthspan compared with standard preventive care. Cost-effectiveness is unstudied. Equity in access is an open problem. Emerging tools should be clearly separated from established clinical practice until trials confirm benefit.

Frequently Asked Questions

Q: What is a longevity clinic?

A: A longevity clinic is a medical practice or testing service that uses advanced diagnostics, risk assessment and personalized plans to extend healthspan. Services range from hospital executive health programs to membership practices and testing platforms. Quality and medical supervision vary widely.

Q: How much does a longevity clinic cost in the USA?

A: Costs range from a few hundred dollars per year for lab-only platforms to more than $20,000 for premium diagnostic memberships. Hospital executive programs are usually quoted individually. Insurance rarely covers these services.

Q: Are longevity clinics medically supervised?

A: Many are, but not all. Hospital programs and physician-led practices employ licensed clinicians. Testing platforms and wellness studios may offer interpretation or no medical oversight. Patients should verify licenses with the state medical board.

Q: Can longevity clinics help extend healthspan?

A: Clinics can help apply proven prevention, such as blood pressure control, exercise and smoking cessation. These measures improve health outcomes. No clinic has demonstrated that advanced testing or experimental therapies extend human lifespan.

Q: What tests do longevity clinics typically perform?

A: Common tests include blood panels, lipid and glucose markers, hormone levels, DEXA body composition and fitness testing. Some add whole-body MRI, coronary calcium scoring, genetic testing and epigenetic clocks. Not every test is backed by clinical guidelines.

Q: Are biological age tests scientifically validated?

A: Epigenetic clocks correlate with mortality in research groups. For individuals, results can vary and no trial has shown that lowering the score extends life. They are best seen as informational.

Q: Do longevity clinics accept health insurance?

A: Most do not accept insurance for memberships or executive programs. Some bill insurance for routine laboratory tests ordered by a physician. Patients should ask about out-of-pocket costs before enrolling.

Q: What is the difference between a longevity clinic and an executive health program?

A: Executive health programs are usually hospital-based, one-time comprehensive evaluations. Longevity clinics often provide ongoing memberships with frequent testing and prescriptions. The two can overlap, and some hospitals now offer longevity services.